A new transmembrane 4 superfamily molecule in the nematode,Caenorhabditis elegans |
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| Authors: | Michael G Tomlinson Mark D Wright |
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| Institution: | (1) MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, England;(2) The Walter and Eliza Hall Institute of Medical Research, Post Office RMH, 3050, Victoria, Australia;(3) Present address: DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, 94304 Palo Alto, CA, USA |
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| Abstract: | Transmembrane 4 superfamily (TM4SF) molecules are predominantly mammalian cell surface glycoproteins that are thought to transduce
signals mediating cell development, activation, and motility. Analysis of the Genpept sequence database reveals YKK8, a novel
member of the TM4SF in the nematode,Caenorhabditis elegans. YKK8 is a putative 27.4-kDa protein encoded by a gene on chromosome III of theC. elegans genome (Wilson et al. 1994]Nature 368:32–38). The assignment of YKK8 to the TM4SF is justified by three criteria: statistical comparison of protein sequences,
conserved TM4SF protein sequence motifs, and conserved TM4SF intron/exon boundaries in the genomic sequence. The discovery
of a TM4SF molecule in the nematode extends this superfamily to a more primitive branch of the phylogenetic tree and suggests
a fundamental role for TM4SF molecules in biology.
Correspondence to: M.G. Tomlinson |
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| Keywords: | Transmembrane 4 superfamily YKK8 Caenorhabditis elegans |
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