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A convenient gram-scale synthesis of uridine diphospho(13C6)glucose |
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| Authors: | Dinev Zoran Wardak Ahmad Z Brownlee Robert T C Williams Spencer J |
| Affiliation: | School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia. |
| Abstract: | A simple gram-scale synthesis of uridine diphospho(13C6)glucose is presented from D-(13C6)glucose. The critical step uses a 1H-tetrazole-catalyzed coupling of 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl-1-phosphate and UMP-morpholidate. The uridine diphospho(13C6)glucose was used in the structural identification of (1-->3)-beta-D-glucan from Lolium multiflorum. |
| Keywords: | Sugar nucleotides UDP-glucose Morpholidate coupling Isotopic labeling Glucan |
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