Premature centromere division (PCD): a dominantly inherited cytogenetic anomaly |
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| Authors: | K. Madan D. Lindhout A. Palan |
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| Affiliation: | (1) Institute of Human Genetics, Medical Faculty, Free University, V. d. Boechorststraat 7, NL-1081 BT Amsterdam, The Netherlands |
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| Abstract: | Summary We describe a family with an increased frequency of cells with premature centromere division (PCD) of all chromosomes in four phenotypically normal individuals. This familial PCD phenomenon is apparently different from the well-described PCD of the X chromosome and from the centromere splitting in cells of patients with Roberts syndrome. Implications for genetic counseling are discussed. |
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