N5-phosphonoacetyl-L-ornithine (PALO): a convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae |
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| Authors: | Johnson Brad Steadman Rachel Patefield Krista D Bunker Jeffrey J Atkin Audrey L Dussault Patrick |
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| Institution: | a Departments of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA
b School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588-0666, USA |
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| Abstract: | A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N5-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism. |
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| Keywords: | PALO Ornithine transcarbamylase Saccharomyces cerevisiae Arginine biosynthesis |
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