Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells by lignans isolated from Euonymus alatus leaves and twigs |
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Authors: | Jeong Eun Ju Cho Jung Hee Sung Sang Hyun Kim Sun Yeou Kim Young Choong |
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Affiliation: | a College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea b Jeollanamdo Development Institute for Traditional Korean Medicine, Jeonnam 529-851, Republic of Korea c Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea |
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Abstract: | The 80% methanolic extract of Euonymus alatus leaves and twigs afforded three new lignans, (−)-threo-4,9,4′,9′-tetrahydroxy-3,7,3′,5′-tetramethoxy-8-O-8′-neolignan (1), (−)-threo-4,9,4′,9′-tetrahydroxy-3,5,7,3′-tetramethoxy-8-O-8′-neolignan (2), (7R,8R,7′R)-(+)-lyoniresinol (3), together with seventeen known lignans (4-20). The structures of 1-20 were elucidated by extensive 1D and 2D spectroscopic methods including 1H NMR, 13C NMR, 1H-1H COSY, HMQC, HMBC and NOESY. All the isolated compounds except for dilignans (19 and 20) significantly inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells. |
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Keywords: | Euonymus alatus Lignan Inflammation Nitric oxide RAW 264.7 |
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