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Triamino pyrimidines and pyridines as histamine H(4) receptor modulators |
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| Authors: | Meduna Steven P Savall Brad M Cai Hui Edwards James P Thurmond Robin L McGovern Patricia M |
| Institution: | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States |
| Abstract: | Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H4 receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds. |
| Keywords: | Pyrimidine Pyridine Histamine Histamine H4 Antagonist |
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