Small-molecule probe using dual signals to monitor leucine aminopeptidase activity |
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Authors: | Yoon Hey Young Shim So Hee Baek Luck Ju Hong Jong-In |
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Affiliation: | a Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea b Department of Microbiology and Institute for Viral Diseases, College of Medicine, Korea University, Seoul 136-705, Republic of Korea |
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Abstract: | Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity. |
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Keywords: | Leucine aminopeptidases Probe Dual signals 2-Dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) unit |
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