Phalloidin reduces the release of inorganic phosphate during actin polymerization |
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| Authors: | P Dancker L Hess |
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| Institution: | Institut für Zoologie, Technische Hochschule Darmstadt, F.R.G. |
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| Abstract: | Phalloidin, an actin-filament stabilizing peptide from Amanita phalloides, did not inhibit ATP hydrolysis during actin polymerization but strongly retarded the release of the hydrolysis product Pi. Thus, the lifetime of the intermediate F-actin-ADP-Pi is significantly increased by phalloidin. The results suggest a close correlation between filament stability and F-actin-ADP-Pi intermediates. |
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