Bacillus cereus cytotoxins Hbl,Nhe and CytK are secreted via the Sec translocation pathway |
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| Authors: | Annette Fagerlund Toril Lindbäck Per Einar Granum |
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| Affiliation: | 1.Norwegian School of Veterinary Science,Department of Food Safety and Infection Biology,Oslo,Norway;2.Laboratory for Microbial Dynamics (LaMDa) and Department of Pharmaceutical Biosciences,University of Oslo,Blindern,Oslo,Norway |
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| Abstract: | Background Bacillus cereus and the closely related Bacillus thuringiensis are Gram positive opportunistic pathogens that may cause food poisoning, and the three secreted pore-forming cytotoxins Hbl, Nhe and CytK have been implicated as the causative agents of diarrhoeal disease. It has been proposed that the Hbl toxin is secreted using the flagellar export apparatus (FEA) despite the presence of Sec-type signal peptides. As protein secretion is of key importance in virulence of a microorganism, the mechanisms by which these toxins are secreted were further investigated. |
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