GLUT4 trafficking in insulin-sensitive cells |
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Authors: | Sally Martin Jan W Slot David E James |
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Institution: | (1) Centre for Molecular and Cellular Biology, and Department of Physiology and Pharmacology, University of Queensland, 4072 Brisbane, QLD, Australia;(2) Department of Cell Biology, Utrecht University Medical School, Utrecht, The Netherlands |
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Abstract: | In recent years, there have been major advances in the under-standing of both the cell biology of vesicle trafficking between
intracellular compartments and the molecular targeting signals intrinsic to the trafficking proteins themselves. One system
to which these advances have been profitably applied is the regulation of the trafficking of a glucose transporter, GLUT4,
from intracellular compartment(s) to the cell surface in response to insulin. The unique nature of the trafficking of GLUT4
and its expression in highly differentiated cells makes this a question of considerable interest to cell biologists. Unraveling
the tangled web of molecular events coordinating GLUT4 trafficking will eventually lead to a greater understanding of mammalian
glucose metabolism, as well as fundamental cell biological principles related to organelle biogenesis and protein trafficking. |
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Keywords: | Intracellular trafficking insulin action glucose transport GLUT4 muscle adipose tissue |
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