Potential application of dot-immunobinding assay as a rapid diagnostic test in tuberculous meningitis |
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| Authors: | V V Radhakrishnan A Mathai |
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| Institution: | Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India. |
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| Abstract: | A simple dot-immunobinding assay (Dot-Iba) in nitrocellulose paper was developed for the detection of specific IgG antibody to Mycobacterium tuberculosis antigen 5 and mycobacterial antigen in cerebrospinal fluid of patients with tuberculous meningitis (TBM). The assay gave 77.1% sensitivity for the detection of IgG antibody to M. tuberculosis antigen 5 and 48.6% sensitivity for the detection of mycobacterial antigen in patients with TBM. |
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