Discovering the strength of immunometabolism in cancer therapy: Employing metabolic pathways to enhance immune responses |
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| Authors: | Huldani Huldani Jitendra Malviya Paul Rodrigues Ahmed Hjazi Maha Medha Deorari Hussein Riyadh Abdul Kareem Al-Hetty Qutaiba A. Qasim Mohammed Qasim Alasheqi Ali Ihsan |
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| Affiliation: | 1. Department of Physiology, Universitas Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia;2. Institute of Advance Bioinformatics, Bhopal, Madhya Pradesh, India;3. Department of Computer Engineering, King Khalid University, Al-Faraa, Asir-Abha, Saudi Arabia;4. Department of Medical Laboratory Sciences, Prince Sattam bin Abdulaziz University College of Applied Medical Sciences, Al-Kharj, Saudi Arabia;5. Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India;6. Department of Biology, College of Education For Pure Sciences, University of Anbar, Ramadi, Anbar, Iraq;7. College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq;8. College of Nursing, National University of Science and Technology, Dhi Qar, Iraq;9. Department of Medical Laboratories Techniques, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq |
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| Abstract: | Immunometabolism, which studies cellular metabolism and immune cell function, is a possible cancer treatment. Metabolic pathways regulate immune cell activation, differentiation, and effector functions, crucial to tumor identification and elimination. Immune evasion and tumor growth can result from tumor microenvironment metabolic dysregulation. These metabolic pathways can boost antitumor immunity. This overview discusses immune cell metabolism, including glycolysis, oxidative phosphorylation, amino acid, and lipid metabolism. Amino acid and lipid metabolic manipulations may improve immune cell activity and antitumor immunity. Combination therapy using immunometabolism-based strategies may enhance therapeutic efficacy. The complexity of the metabolic network, biomarker development, challenges, and future approaches are all covered, along with a summary of case studies demonstrating the effectiveness of immunometabolism-based therapy. Metabolomics, stable isotope tracing, single-cell analysis, and computational modeling are also reviewed for immunometabolism research. Personalized and combination treatments are considered. This review adds to immunometabolism expertise and sheds light on metabolic treatments' ability to boost cancer treatment immunological response. Also, in this review, we discussed the immune response in cancer treatment and altering metabolic pathways to increase the immune response against malignancies. |
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| Keywords: | cancer immune response immunometabolism metabolic pathways |
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