Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus. |
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| Authors: | H Rigter R B Messing B J Vasquez R A Jensen J L Martinez J C Crabbe J L McGaugh |
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| Institution: | 1. CNS Pharmacology Department, Scientific Development Group, Organon, Oss, The Netherlands;2. Department of Psychobiology, University of California at Irvine, Irvine, California 92717, U.S.A. |
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| Abstract: | The regional distribution of stereospecific 3H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of 3H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides. |
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