p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas |
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| Authors: | Redman A M Johnson J S Dally R Swartz S Wild H Paulsen H Caringal Y Gunn D Renick J Osterhout M Kingery-Wood J Smith R A Lee W Dumas J Wilhelm S M Housley T J Bhargava A Ranges G E Shrikhande A Young D Bombara M Scott W J |
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| Institution: | Department of Chemistry Research, Bayer Research Center, Pharmaceutical Division, West Haven, CT 06516, USA. aniko.redman.b@bayer.com |
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| Abstract: | Inhibitors of the MAP kinase p38 are potentially useful for the treatment for osteoporosis, arthritis, and other inflammatory diseases. A series of thienyl, furyl, and pyrrolyl ureas has been identified as potent p38 inhibitors, displaying in vitro activity in the nanomolar range. |
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