Virulence of silver-resistant mutant ofKlebsiella pneumoniae in burn wound model |
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| Authors: | L K Gupta R Jindal H K Beri S Chhibber |
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| Institution: | (1) Department of Microbiology, Panjab University, 160 014 Chandigarh, India;(2) Present address: Central Institute of Fishery Technology, 400 005 Bombay, India |
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| Abstract: | A silver-resistant mutant ofKlebsiella pneumoniae B-5 was produced by passaging in nutrient broth containing graded concentrations of silver nitrate up to 150 ppm. The development
of silver resistance in the strain resulted in rough colonies, decrease in cell size, carbohydrate content and change in klebocin
pattern. The virulence of the AgR strain as checked by the burn wound model decreased as the mutant could not establish itself in the skin and spleen of the
animals and the organism was cleared more efficiently by human lymphocytes than the parent AgS strain. |
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