Melatonin increases the survival time of animals with untreated mammary tumours: Neuroendocrine stabilization |
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| Authors: | M. C. Saez C. Barriga J. J. Garcia A. B. Rodriguez J. Masot E. Duran E. Ortega |
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| Affiliation: | (1) INRA, Unité Mixte de Recherche Systèmes d’Elevage et Nutrition Animale et Humaine, Domaine de la Prise, Saint-Gilles, France;(2) INRA, Unité Mixte de Recherche Systèmes d’Elevage et Nutrition Animale et Humaine, Domaine de la Prise, 35590 Saint-Gilles, France |
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| Abstract: | Mitochondrial respiratory rates and regulation by phosphate acceptors were studied on permeabilized fiber bundles differing in their myosin heavy chain profiles. The acceptor control ratio, an indicator of oxidation to phosphorylation coupling, and mitochondrial Km for ADP were the highest in type I, intermediate in mixed IIa/IIx and the lowest in IIx and predominantly IIb fiber bundles. A functional coupling between mitochondrial creatine kinase and oxidative phosphorylation occurred in type I and IIa/IIx fiber bundles, exclusively. Our study suggests that mitochondrial functioning in fast IIa fibers is closer to that of the slow/I than fast IIx or IIb fibers. (Mol Cell Biochem 276: 15–20, 2005) |
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| Keywords: | mitochondrial creatine kinase mitochondrial respiration regulation myosin heavy chain oxidative phosphorylation saponin-skinned muscle fiber |
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