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Origin ofd-serine present in urine of mutant mice lackingd-amino-acid oxidase activity
Authors:S Asakura  Dr R Konno
Institution:(1) Department of Oral Surgery, Dokkyo University School of Medicine, Mibu, 321-02 Tochigi, Japan;(2) Department of Microbiology, Dokkyo University School of Medicine, Mibu, 321-02 Tochigi, Japan
Abstract:Summary Urine of ddY/DAO mice lackingd-amino-acid oxidase contained 5.7 times more serine than that of normal ddY/DAO+ mice. Most of the serine wasd-isomer. The origin of thisd-serine was examined. Oral administration of 0.02% amoxicillin and 0.004% minocycline to the ddY/ DAO- mice for 7 days did not reduce the urinaryd-serine, indicating that thed-serine was not of intestinal bacterial origin. When the mouse diet was changed to one with different compositions, the urinaryd-serine was considerably reduced. Furthermore, starvation of the ddY/DAO- mice for 24 hours reduced the urinaryd-serine to 33% of the original level. These results indicate that most of the urinaryd-serine comes from the diet. However, the urine of the starved ddY/DAO- mice still contained 4.6 times mored-serine than that of the ddY/DAO+ mice, suggesting a part of the D-serine have an endogenous origin.
Keywords:d-Serine" target="_blank">d-Serine  Urine  Mouse  d-Amino-acid oxidase" target="_blank">d-Amino-acid oxidase  d-Amino acids" target="_blank">d-Amino acids
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