| 神经肽Y_2受体对神经病理痛调制的研究进展 |
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| 引用本文： | 时培晟,王栓科,王永刚,周海宇.神经肽Y_2受体对神经病理痛调制的研究进展[J].现代生物医学进展,2013,13(1):191-193. |
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| 作者姓名： | 时培晟 王栓科 王永刚 周海宇 |
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| 作者单位： | 1. 兰州军区兰州总医院 甘肃兰州730000
2. 兰州大学第二医院骨科 甘肃兰州730000;甘肃省骨关节疾病重点实验室 甘肃兰州730000 |
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| 基金项目： | 甘肃省科技厅技术研究与开发专项计划(1004TCYA040);中央高校基本科研项目(lzujbky-209-155) |
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| 摘 要： | 神经肽Y2受体（neuropeptideY2 receptor,NPY2R）是一种在很多生理及病理情况下广泛分布、表达于哺乳动物的G蛋白耦联受体。Y2受体在众多生理作用及疾病中发挥重要影响,通过神经肽Y在脊髓及脊髓以上水平的作用,Y2受体对神经病理痛的形成有密切联系。本文拟从Y2受体分子生物学基础、相关的作用机制及涉及神经病理痛实验研究方面,就Y2受体对痛觉调制中的作用作简单综述。
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| 关 键 词： | 神经肽Y2受体 痛觉 神经系统 |
Recent Advances in Pain Modulation by NeuropeptideY2 Receptor |
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| SHI Pei-sheng,WANG Shuan-ke,WANG Yong-gang,ZHOU Hai-yu.Recent Advances in Pain Modulation by NeuropeptideY2 Receptor[J].Progress in Modern Biomedicine,2013,13(1):191-193. |
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| Authors: | SHI Pei-sheng WANG Shuan-ke WANG Yong-gang ZHOU Hai-yu |
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| Institution: | 2,3△(1 Lanzhou General Hospital of Lanzhou Military Area Command,Gansu,Lanzhou,730000,China; 2 Department of Osteology,The Second hospital of Lanzhou University,Gansu,Lanzhou,730000,China; 3 Orthopeadics Key Laboratory of Gansu Province,Lanzhou,730000,China) |
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| Abstract: | The neuropeptide Y2 receptor （NPY2R） is widely distributed and well expressed in the mammal, with a multitude of physiological and pathological connections. This is a G-protein coupling receptor with seven transmernbrane helices, a member of the largest group of plasma membrane receptors. We briefly survey the current knowledge and concepts regarding structure and function of the neuropeptide Y2 receptor and its evidences in experiments, especially as related to mechanisms of researches and its roles in pain processing. |
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| Keywords: | NPY2R Pain Neuron System |
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