Plasma levels and urinary excretion of amino acids by subjects with renal calculi |
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Authors: | Stoyanka Slavcheva Atanassova P Panchev M Ivanova |
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Institution: | (1) Department of Urology, Alexandrov’s University Hospital, Medical University, “G. Sofiisky” Blvd 1, 1431 Sofia, Bulgaria;(2) National Genetic Laboratory, Alexandrov’s University Hospital, Sofia, Bulgaria |
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Abstract: | Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects
and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases
with pure uric acid stones; (3) 10 cases with magnesium-ammonium phosphate stones, either pure or mixed with apatite. Some
types of stones (namely oxalate and uric acid calculi) are mainly formed as a result of a metabolic deficiency that may affect
the amino acid metabolism, and thus may be reflected in the urinary amino acid pattern. Data demonstrated clearly that there
is a general tendency towards decreased amino acid excretions in all SFs with all types of stones. As a whole, one can observe
a higher percentage of patients with calcium oxalate and phosphate calculosis, who have low urine excretions of amino acids;
about 50% are the SFs with lower urine excretion of serine, glycine, taurine and i-leucine; the high percentage of patients with CaOX calculi shows lower urine excretions of tyrosine and ornithine. |
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