Reduction induced by substance P of the initial accumulation of myo(3H)inositol in acinar cells of the parotid gland in rats |
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| Authors: | Y Torrens M Dietl J C Beaujouan J Glowinski |
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| Institution: | Collège de France, Chaire de Neuropharmacologie, I.N.S.E.R.M. n. U 114, Paris. |
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| Abstract: | The stimulation of rat parotid acinar cells by substance P(SP) resulted in a significant reduction in the initial accumulation of cytosolic myo3H]inositol and in the initial labelling of phosphoinositides. The SP-induced reduction was concentration-dependent, the EC50 of SP was 5.8 +/- 2.5 nM. Spantide, D-Arg1, D-Trp7,9, Leu11]SP, a SP antagonist, used at a concentration of 10(-5) M, competitively shifted the dose-response curve of SP. The pharmacological analysis of the effects of several tachykinins and analogues, suggests the implication of NK1 receptors (specific receptor of SP). |
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