Changes in the physicochemical characteristics of rabbit sclera upon scleral reinforcement |
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| Authors: | N Yu Ignat’eva S V Averkiev E N Iomdina Zh N Ivashchenko L A Baratova E V Lukashina V V Lunin |
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| Institution: | (1) Chemical Faculty, Moscow State University, Moscow, 119899, Russia;(2) Helmholtz Research Institute for Eye Diseases, Moscow, 105062, Russia;(3) Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119899, Russia |
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| Abstract: | Biochemical analysis and differential scanning calorimetry demonstrated that the connective tissue (capsule) formed around a reinforcing scleroplastic implant is similar to intact sclera, its main component being type I collagen organized in perfect fibrils with cross-linking sufficient for normal thermomechanical properties. DSC also revealed a fraction of collagen with heat-labile ‘immature’ cross-links around implants containing a stimulatory plant product Panaxel, which suggested high synthetic activity of fibroblasts. |
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| Keywords: | collagen differential scanning calorimetry scleroplasty |
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