Action of hypoxic sensitizers on the survival of haplont yeasts irradiated with ionizing radiation

A study was made of the oxygen effect and the radiosensitizing action of metronidazole and misonidazole on hypoxic cells of irradiated yeast haplonts. It was shown that metronidazole did not increase the radiosensitivity of all the strains under study while the sensitizing effectiveness of oxygen and misonidazole approximated the values characteristic of different repair-deficient rad-mutants. Possible causes of the radiosensitizing effects observed are discussed.