Solution-phase secondary-ion mass spectrometry of protonated amino acids |
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| Authors: | G R Pettit G M Cragg C W Holzapfel A A Tuinman D P Gieschen |
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| Institution: | 1. Cancer Research Institute, Arizona State University, Tempe, Arizona 85287 USA;2. Department of Chemistry, Arizona State University, Tempe, Arizona 85287 USA;1. Institut Pasteur Guadeloupe, Morne Joliviere, 97139 Les Abymes, Guadeloupe, France;2. Université de Liège, LEAE -CART, Freshwater and Oceanic Sciences Unit of Research (FOCUS), B6C, Allée du 6 Août, 11, 4000 Liège, Belgium;3. Université de Liège, CART, Molecular Systems Unit of Research (MolSys), B6C, Allée du 6 Août, 11, 4000 Liège, Belgium;1. Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands;2. Department of PharmacoTherapy, -Epidemiology and -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands;3. Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;4. Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands;1. German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Str. 8-10, Berlin, Germany;2. University of Potsdam, Institute of Nutritional Science, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany;3. Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Dermatology, Venereology and Allergology, Clinical Research Center for Hair and Skin Science, Charitéplatz 1, 10117 Berlin, Germany |
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| Abstract: | Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondary-ion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations. |
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