The role of RNA and RNA-related proteins in the regulation of DNA double strand break repair pathway choice |
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| Affiliation: | 1. Departamento de Genética, Universidad de Sevilla, Sevilla, 41080, Spain;2. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, 41092, Spain;1. Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, 11794, USA;2. Biochemistry and Structural Biology graduate program, Stony Brook University, New York 11794, USA;3. Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, 11794, USA;1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA;2. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, 77030, USA;3. Robert and Janice McNair Foundation/ McNair Medical Institute M.D./Ph.D. Scholars Program, Baylor College of Medicine, Houston, TX, 77030, USA;4. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA;5. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA;1. Molecular and Cellular Biology Graduate Program and Medical Scientist Training Program, University of Washington, Seattle, WA, USA;2. Department of Biochemistry, Vanderbilt University, Nashville, TN, 37205, USA;3. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA |
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| Abstract: | DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation of resection by RNA molecules and RNA-related proteins. Moreover, we aim to reconcile contradictory reports on the positive or negative effect of DNA:RNA hybrids in the resection process. |
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| Keywords: | DNA double strand break repair Homologous recombination NHEJ RNA R-loops |
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