A new perspective on oxidation of DNA repair proteins and cancer |
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| Affiliation: | 1. Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California;2. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;1. Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, España;2. Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, España;3. Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, España;1. University of Illinois College of Medicine, Department of Biomedical Sciences, Rockford, IL, 61107, United States;2. University of Illinois College of Pharmacy, Biopharmaceutical Sciences Department, Rockford IL, 61107, United States;1. Vocational School of Health Services, Izmir University of Economics, Izmir, Turkey;2. Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey;3. Department of Molecular Medicine, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey;4. Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD, 20892, USA;5. Department of Psychiatry, School of Medicine, Dokuz Eylul University, Izmir, Turkey;6. Department of Psychiatry, Mardin State Hospital, Mardin, Turkey;7. Department of Psychology, Istanbul Gelişim University, Istanbul, Turkey, Turkey;8. Department of Medical Biochemistry, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey;9. Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA |
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| Abstract: | Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS can saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted for oxidative modifications, including DNA and protein. The oxidation of DNA, which leads to base modification and formation of abasic sites along with single and double strand breaks, has been extensively investigated. Protein oxidation is often neglected and is only recently being recognized as an important regulatory mechanism of various DNA repair proteins. This is a review of the current state of research on the regulation of DNA repair by protein oxidation with emphasis on the correlation between inflammation and cancer. |
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| Keywords: | Oxidative stress DNA damage Oxidation of DNA repair proteins Double strand break repair Base excision repair |
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