Multi-species okadaic acid contamination and human poisoning during a massive bloom of Dinophysis acuminata complex in southern Brazil |
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Affiliation: | 1. Ocean Sciences Department, 1156 High Street, University of California, Santa Cruz, CA, 95064, United States;2. Department of Oceanography, Texas A&M University, College Station, TX, 77843, United States;1. Food Safety Group, Centre for Environment, Fisheries and Aquaculture Science, Barrack Road, Weymouth, Dorset DT4 8UB, UK;2. Scottish Association for Marine Science, Scottish Marine Institute, Oban, PA37 1QA, Scotland, UK;3. Aquatic Pathogens and Pests, Centre for Environment, Fisheries and Aquaculture Science, Barrack Road, Weymouth, Dorset DT4 8UB, UK;4. Phytoplankton Laboratory, Centre for Environment, Fisheries and Aquaculture Science, Pakefield Road, Lowestoft, Suffolk NR33 0HT, UK;1. Instituto Español de Oceanografía (IEO), Centro Oceanográfico de Vigo, Subida a Radio Faro 50, 36390 Vigo, Spain;2. Instituto de Investigacións Mariñas (IIM-CSIC), Eduardo Cabello 6, 36208 Vigo, Spain;3. Institute for Bio-Organic Chemistry "Antonio González" (IUBO-AG), University of La Laguna, Avda. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain;4. Instituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avda Astrofísico Francisco Sánchez 3, 38206 La Laguna, Spain |
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Abstract: | On June 2016, a major bloom of Dinophysis acuminata complex was noticed over the coast of Paraná State (PR), southern Brazil, an area unprotected by any official monitoring program. Here we report the results of an extensive sampling effort that ultimately led PR authorities to issue the first State shellfish-harvesting ban due to multi-species okadaic acid (OA) contamination. During its peak, the bloom covered an area of 201 km2 (∼2.0–3.5 × 54.0 km), attaining unprecedentedly high cell densities along the shallow (<15 m) continental shelf (mean 2.2 × 105, maximum 2.1 × 106 cells L−1) and adjacent sandy beaches (mean 2.8 × 105, maximum 5.2 × 106 cells L−1). Only OA was detected in suspension (max. 188 ng L−1). Toxin levels measured in bivalves were several times greater than the regulatory limit of 160 ng g−1, reaching up to 3600 ng g−1 in Crassostrea gasar, by far the highest OA concentrations ever reported in oysters worldwide, 7700 ng g−1 in brown mussels, Perna perna, and lower levels in clams, Anomalocardia brasiliana, and mangrove mussels, Mytella spp. Nine cases of human intoxication were officially reported and five people were hospitalized with typical symptoms of Diarrhetic Shellfish Poisoning linked to the consumption of contaminated bivalves. All bivalves quickly converted most of the OA into its esterified form, DTX-3, and eliminated the toxins only a few weeks following the bloom, with C. gasar being the slowest-detoxifying species. Lower OA levels were accumulated in zooplankton, gastropods and several novel toxin vectors, including benthic organisms such as sand dollars Mellita quinquiesperforata and the ghost-shrimp Callichirus major, which may act as a good indicator of the presence of toxins in sandy beaches, and pelagic fish species that can serve as potential alternative sources of OA to humans (Chaetodipterus faber and Mugil liza). Monitoring toxin contamination in seafood other than bivalves is thus recommended to ensure comprehensive human health protection during massive Dinophysis blooms. Additionally, since OA was also present at low concentrations in the liver of Guiana dolphins Sotalia guianensis and penguins Spheniscus magellanicus, exposure to biotoxins should be considered in conservation actions involving threatened and near-threatened marine organisms in this region. |
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Keywords: | Harmful algae DSP Lipophilic toxins Toxin in food webs Seafood intoxication New toxin vectors |
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