The effect of A23187 on glucose production from methylglyoxal and pyruvate in isolated murine hepatocytes. |
| |
| Authors: | M P Kalapos P Riba T Garzó F Antoni J Mandl |
| |
| Institution: | Semmelweis University, Medical School, First Institute of Biochemistry, Budapest, Hungary. |
| |
| Abstract: | 1. A23187 increased the glucose production from methylglyoxal in isolated hepatocytes, and maximal stimulation was obtained at 10(-6) M. The effect of A23187 was dependent on the presence of Ca2+. 2. Glucose production from pyruvate (less than 1 mM) in isolated hepatocytes was stimulated by A23187 in the presence of 2.5 mM Ca2+ and was depressed at pyruvate concentrations above 1 mM. Both the virtual Km and the virtual Vmax of glucose production from pyruvate were decreased by A23187. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
