Protein sequence tags: a novel solution for comparative proteomics |
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Authors: | Kuhn Karsten Prinz Thorsten Schäfer Jürgen Baumann Christian Schärfke Marco Kienle Stefan Schwarz Josef Steiner Sandra Hamon Christian |
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Institution: | Proteome Sciences R&D, Frankfurt am Main, Germany. |
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Abstract: | Comparative proteome profiling using stable isotope peptide labelling and mass spectrometry has emerged as a promising strategy. Here, we show the broad potential of our proprietary protein sequence tag (PST) technology. A special feature of PST is its ability to detect a wide variety of proteins including the pharmaceutically relevant membrane and nuclear proteins. This procedure addresses a similar number of proteins, compared to the multidimensional protein identification technology approach, but offers additionally a quantitative analysis with its recently developed quantitative PST version. |
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