Hydroxylated anthraquinones produced by Geosmithia species |
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Authors: | E Stodůlková M Kolařík Z Křesinová M Kuzma M Šulc P Man P Novák P Maršík P Landa J Olšovská M Chudíčková S Pažoutová J Černý J Bella M Flieger |
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Institution: | E. Stodůlková, M. Kolařík, Z. Křesinová, M. Kuzma, M. Šulc, P. Man, P. Novák, P. Maršík, P. Landa, J. Olšovská, M. Chudíčková, S. Pažoutová, J. Černy, J. Bella and M. Flieger |
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Abstract: | Geosmithia fungi are little known symbionts of bark beetles. Secondary metabolites of lilac colored species G. lavendula and other nine Geosmithia species were investigated in order to elucidate their possible role in the interactions of the fungi with environment. Hydroxylated
anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during
the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G+-bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64–512 μg/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2
was found only for compound 3 at 1 and 10 μg/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines. |
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