An ISCT Stem Cell Engineering Committee Position Statement on Immune Reconstitution: the importance of predictable and modifiable milestones of immune reconstitution to transplant outcomes |
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| Affiliation: | 1. Center for Cancer and Immunology Research, CETI, Children''s National Hospital, Washington, District of Columbia, USA;2. Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, California, USA;3. Stem Cell Transplantation and Cellular Therapies, Memorial Sloan Kettering Cancer Center, and Department of Pediatrics, Weill Cornell Medical College of Cornell University, New York, New York, USA;4. Pediatric Bone Marrow Transplantation Division, Hospital Pequeno Principe, Curitiba, Brazil;5. Université de Montréal and Maisonneuve Rosemont Hospital, Montréal, Québec, Canada;6. Stem Cell Transplant Program, Division of Hematology/Oncology Boston Children''s Hospital and Department of Pediatric Oncology, Dana Farber Cancer Institute;7. Department of Haematology, Fiona Stanley Hospital, Perth, Western Australia, Australia;8. IRCCS Ospedale San Raffaele, Segrate, Milan, Italy;9. University of Vermont, Burlington, Vermont;10. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom |
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| Abstract: | Allogeneic stem cell transplantation is a potentially curative therapy for some malignant and non-malignant disease. There have been substantial advances since the approaches first introduced in the 1970s, and the development of approaches to transplant with HLA incompatible or alternative donors has improved access to transplant for those without a fully matched donor. However, success is still limited by morbidity and mortality from toxicity and imperfect disease control. Here we review our emerging understanding of how reconstitution of effective immunity after allogeneic transplant can protect from these events and improve outcomes. We provide perspective on milestones of immune reconstitution that are easily measured and modifiable. |
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| Keywords: | T cells |
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