Post-acute anti-NMDAR encephalitis mirrors schizophrenia |
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| Institution: | 1. French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Lyon, France;2. MeLiS - UCBL-CNRS UMR 5284 - INSERM U1314, Université Claude Bernard Lyon 1, Lyon, France;3. Stanford Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA;4. Clinical Neurology, Santa Maria Della Misericordia University Hospital, Azienda Ospedaliera Universitaria Friuli Centrale (ASU FC), Udine, Italy;1. Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany;2. Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany;1. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA;2. Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA;3. Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA;4. Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA;1. Microbiology Department, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, PA, USA;2. Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, PA, USA;3. Department of Pediatrics, Children''s Hospital of Philadelphia Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA;4. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;1. Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA;1. Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;1. National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa;2. SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;3. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa;4. Centre for the AIDS Programme of Research in South Africa (CAPRISA), KwaZulu-Natal, South Africa, Discipline of Virology, University of KwaZulu-Natal, South Africa |
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| Abstract: | The post-acute evolution of the cognitive and psychiatric features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been poorly investigated so far. In recent work published in Lancet Neurology, Guasp et al. report that the neuropsychiatric symptoms of the post-acute phase mirror those observed in schizophrenia, although only patients with anti-NMDAR encephalitis showed improvements of their symptoms. |
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