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siRNA modification and delivery for drug development
Affiliation:1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China;2. Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China;3. Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China;4. School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China;5. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China;6. Rigerna Therapeutics, Suzhou, Jiangsu 215127, China;1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;2. Center for Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA;1. Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA;2. Center for Genome Integrity, Washington University in St. Louis, St. Louis, MO, USA;3. Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO, USA;4. Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;5. Department of Biochemistry and Biofrontiers Instiute, University of Colorado, Boulder, CO, USA;6. Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA;7. Howard Hughes Medical Institute, Chevy Chase, MD, USA;1. Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 157 84, Greece;2. Department of Clinical Therapeutics, School of Medicine, Alexandra General Hospital, National and Kapodistrian University of Athens, Athens, 115 28, Greece;3. Hematology Laboratory–Blood Bank, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 28, Athens, Greece;4. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 115 27, Athens, Greece;5. Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 157 01, Greece;6. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, 115 27, Greece;1. Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Abstract:
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