Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues |
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| Authors: | Matthijs van der Knaap, Eefje Engels, Henk J. Busscher, Jos M. Otero, Antonio L. Llamas-Saiz, Mark J. van Raaij, Roos H. Mars-Groenendijk, Daan Noort, Gijsbert A. van der Marel, Herman S. Overkleeft,Mark Overhand |
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| Affiliation: | Matthijs van der Knaap, Eefje Engels, Henk J. Busscher, José M. Otero, Antonio L. Llamas-Saiz, Mark J. van Raaij, Roos H. Mars-Groenendijk, Daan Noort, Gijsbert A. van der Marel, Herman S. Overkleeft,Mark Overhand, |
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| Abstract: | The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified d-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. |
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| Keywords: | Anti-microbial peptides Gramicidin S derivatives Biological profile |
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