Reduction of overall Helicobacter pylori colonization levels in the stomach of Mongolian gerbil by Lactobacillus johnsonii La1 (LC1) and its in vitro activities against H. pylori motility and adherence |
| |
| Authors: | Isobe Hirokazu Nishiyama Akihito Takano Tomomi Higuchi Wataru Nakagawa Saori Taneike Ikue Fukushima Yoichi Yamamoto Tatsuo |
| |
| Affiliation: | Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. |
| |
| Abstract: | The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
