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Serum lactate dehydrogenase isoenzyme 1 activity in patients with testicular germ cell tumors correlates with the total number of copies of the short arm of chromosome 12 in the tumor |
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| Authors: | Finn Edler Eyben Willem E Graaff Jan Marrink Ole Blaabjerg Dirk Th Sleijfer Heimen Schraffordt Koops J Wolter Oosterhuis Per Hyltoft Petersen Jannie Echten-Arends and Bauke Jong |
| Institution: | (1) Department of Clinical Chemistry, Odense University Hospital, Odense, Denmark;(2) Department of Pathology, University Hospital of Groningen, Groningen;(3) Department of Internal Medicine, University Hospital of Groningen, Groningen;(4) Department of Surgical Oncology, University Hospital of Groningen, Groningen;(5) Department of Medical Genetics, University Hospital of Groningen, Groningen;(6) Dr. Daniel den Hoed Cancer Center Rotterdam, Rotterdam, The Netherlands;(7) Present address: Dept. Internal Medicine, Fylkessjukhuset i laerdal, N-5890 Laerdal, Norway |
| Abstract: | Summary The aim of our study was to assess the relationship between the serum lactate dehydrogenase isoenzyme 1 (S-LDH-1) activity in patients with testicular germ cell tumors and the number of copies of the short arm of chromosome 12 (12p) present in tumor. Twenty-seven adult patients with measurable tumor lesions were studied. Twenty-five had three or more copies of chromosome 12 per cell in the tumors. Nineteen had one or more copies of a specific chromosomal abnormality, an isochromosome of the short arm of chromosome 12, i(12p). Fourteen had increased S-LDH-1 levels. S-LDH-1 activity correlated significantly with the product of total tumor volume and the total number of copies of the short arm of chromosome 12 present per cell (total tumor 12p). We conclude that the total number of copies of the short arm of chromosome 12 in the tumors is most probably a factor contributing to the LDH-1 activity released from the tumors. |
| Keywords: | Testicular neoplasms Lactate dehydrogenase isoenzymes Cytogenetics |
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