Novel SNPs of the mtDNA ND5 Gene and Their Associations with Several Growth Traits in the Nanyang Cattle Breed |
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| Authors: | Bao Zhang Hong Chen Liushuai Hua Chunlei Zhang Xiangtao Kang Xinzhuang Wang Chuanying Pan Xianyong Lan Chuzhao Lei |
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| Affiliation: | (1) College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P.R. China;(2) Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou, Jiangsu, 221116, P.R. China;(3) Research Center of Cattle Engineering Technology in Henan, Zhengzhou, Henan, 450003, P.R. China |
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| Abstract: | Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six breeds were 0.041–0.167. Polymorphism of the ND5 gene was shown to be associated with growth in the Nanyang breed. Individuals with haplotype B had greater hucklebone width than those with haplotype A when 6 months old (P < 0.01), as well as better body height, body length, body weight, and average daily gain at 6 months (P < 0.05). Therefore, haplotype B of the ND5 gene was likely to have a positive effect on growth traits at 6 months in the Nanyang breed. |
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| Keywords: | Cattle mtDNA ND5 gene Polymorphism Single nucleotide polymorphism (SNP) Growth traits |
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