Determinants of plasma uric acid |
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| Authors: | C L Gulbrandsen N E Morton D C Rao G G Rhoads A Kagan |
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| Institution: | (1) Department of Medicine, University of Hawaii, 96822 Honolulu, HI, USA;(2) Population Genetics Laboratory, University of Hawaii, 96822 Honolulu, HI, USA;(3) School of Public Health, University of Hawaii, 96822 Honolulu, HI, USA |
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| Abstract: | Summary Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied. |
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