Mechanism of the effect of levorin on transport of amino acids inCandida albicans |
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Authors: | A S Obukhovskaya E B Lishnevskaya I M Tereshin |
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Institution: | (1) The USSR Research Technological Institute of Antibiotics and Enzymes for Medical Use, Ogorodnikov Prospekt, 41, 198020 Leningrad, USSR |
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Abstract: | By use of incubation media of various ionic compositions and pH's, it was possible to reveal that inhibition of the transport
of neutral amino acids having long hydrophobic chains (leucine, phenylalanine) inCandida albicans by the polyene antibiotic levorin was mainly due to redistribution—caused by the antibiotic—of monovalent cations in the
cells and protoplasts of the yeast. In an acidic medium, levorin was also found to induce a decrease of proton release from
the cells, accompanied by some inhibition of leucine transport. Transport of neutral amino acids having short hydrophobic
chains (alanine, glycine, proline) was inhibited by this polyene antibiotic, irrespective of the ionic composition or pH of
the medium. |
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Keywords: | |
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