Natural products as catalysts for innovation: a pharmaceutical industry perspective |
| |
Authors: | Schmitt Esther K Moore Charles M Krastel Philipp Petersen Frank |
| |
Institution: | Natural Products Unit, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Switzerland |
| |
Abstract: | Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|