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Incorporation of lycopene into chylomicron remnant-like particles enhances their induction of lipid accumulation in macrophages |
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| Authors: | Moore Elizabeth H Napolitano Mariarosaria Prosperi Antonella Avella Michael Suckling Keith E Bravo Elena Botham Kathleen M |
| Affiliation: | a Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St., London NW1 0TU, UK b Istituto Superiore di Sanita, Laboratory of Metabolism and Pathological Biochemistry, Viale Regina Elena, Rome 00161, Italy c Glaxo SmithKline, Medicines Research Centre, Gunnels Wood Rd, Stevenage, Herts SG1 2NY, UK |
| Abstract: | Lipid accumulation in macrophages exposed to chylomicron remnant-like particles containing the dietary antioxidant lycopene was investigated. After incubation with THP-1 macrophages (48 h), chylomicron remnant-like particles containing lycopene (lycCRLPs) as compared to those without (CRLPs) caused significantly more lipid accumulation in the cells, and this was due to increases in both the triacylglycerol (+100%) and cholesterol (+62%) content. In addition, expression of mRNA for diacylglycerol acyltransferase (DGAT), a key enzyme in triacylglycerol synthesis, was significantly decreased by lycCRLPs, but not CRLPs. These findings suggest that lycopene from the diet may promote, rather than retard, lipid accumulation in macrophages during its transport in the blood in chylomicron remnants. |
| Keywords: | Chylomicron remnants Macrophages Lycopene Dietary lipids Dietary antioxidants Triacylglycerol Cholesterol |
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