Carbon tetrachloride activation in liver microsomes from rats induced with 3-methylcholantrene |
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| Authors: | J A Castro C R De Castro N D'Acosta M I Diaz Gomez E C De Ferreyra |
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| Institution: | Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina |
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| Abstract: | The irreversible binding of14C from14CCl4 to microsomal lipids is decreased in animals treated with 3-methylcholantrene (3-MC), while it is increased in animals induced with phenobarbital (PB). CCl4-induced lipid peroxidation in 3-MC treated rats is as intense as in controls. Destruction of glucose 6-phosphatase (G6P-ase) by CCl4 is smaller in 3-MC treated rats than in controls. Destruction of total cytochrome P-450 (P-450 + P1-450) by CCl4 is smaller in 3-MC treated than in PB treated rats but similar to that obtained in controls. Results would indicate that P-450 would participate in CCl4 activation much more effectively than P1-450. |
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