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Preparation, characterization, and antibacterial activity of oleic acid-grafted chitosan oligosaccharide nanoparticles
Authors:Lu Huang  Xiaojie Cheng  Chengsheng Liu  Ke Xing  Jing Zhang  Gangzheng Sun  Xiaoyan Li  Xiguang Chen
Institution:1. College of Marine Life Science, Ocean University of China, Qingdao, 266003, China
Abstract:An oleic acid-grafted chitosan oligosaccharide (CSO-OA) with different degrees of amino substitution (DSs) was synthesized by the 1-ethyl-3-(3-dimethylami-nopropyl) carbodiimide (EDC)-mediated coupling reac-tion. Fourier transform infrared spectroscopy (FT-IR) suggested the formation of an amide linkage between amino groups of chitosan oligosaccharide and carboxyl groups of oleic acid. The critical aggregation concentra-tions (CACs) of CSO-OA with 6%, 11%, and 21% DSs were 0.056, 0.042, and 0.028mg·mL-1, respectively. Nanoparticles prepared with the sonication method were characterized by means of transmission electron micro-scopy (TEM) and Zetasizer, and the antibacterial activity against Escherichia coli and Staphylococcus aureus was investigated. The results showed that the CSO-OA nanoparticles were in the range of 60-200 nm with satisfactory structural integrity. The particle size slightly decreased with the increase of DS of CSO-OA. The antibacterial trial showed that the nanoparticles had good antibacterial activity against E. coli and S. aureus.
Keywords:chitosan oligosaccharide  nanoparticles  anti-microbial activity
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