Concentration polarization of atherogenic lipids in the arterial system |
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Authors: | Email author" target="_blank">Xiaoyan?DengEmail author Guixue?Wang |
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Institution: | 1. Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, Chongqing 400044, China;State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116023, China 2. Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, Chongqing 400044, China |
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Abstract: | The transport of atherogenic lipids (LDL) in a straight segment of an artery with a semi-permeable wall was simulated numerically.
The numerical analysis predicted that a mass transport phenomenon called ’concentration polarization’ of LDL might occur in
the arterial system. Under normal physiological flow conditions, the luminal surface LDL concentration was 5%–14% greater
than the bulk concentration in a straight segment of an artery. The luminal surface LDL concentration at the arterial wall
was flow-dependent, varying linearly with the filtration rate across the arterial wall and inversely with wall shear rate.
At low wall shear rate, the luminal surface LDL concentration was very sensitive to changes in flow conditions, decreasing
sharply as wall shear rate increased. In order to verify the numerical analysis, the luminal surface concentration of bovine
serum albumin (as a tracer macromolecule) in the canine carotid artery was measured in vitro by directly taking liquid samples from the luminal surface of the artery. The experimental result was in very good agreement
with the numerical analysis. The authors believe that the mass transport phenomenon of ‘concentration polarization’ may indeed
exist in the human circulation and play an important role in the localization of atherosclerosis. |
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Keywords: | mass transport concentration polarization wall shear rate atherosclerosis |
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