Immunological effects of recombinant feline interferon-omega (KT-80) administration in the dog |
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Authors: | Kuwabara Masato Nariai Youko Horiuchi Yutaka Nakajima Yuko Yamaguchi Yu Horioka Eriko Kawanabe Mikiko Kubo Takuya Yukawa Masayoshi Sakai Takeo |
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Affiliation: | Department of Veterinary Radiology, College of Bioresource Science, Nihon University, Fujisawa, Kanagawa Japan. kuwabara@bru.nihon-u.ac.jp |
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Abstract: | The immunological effects of recombinant feline interferon-omega (rFeIFN-omega ; KT-80, Toray) were examined on administration to healthy dogs. The activities of whole blood cells, macrophages, and natural killer cells were enhanced. Moreover, the whole blood activity was examined when KT-80 was administered to dogs which had been diagnosed as having natural canine parvovirus (CPV) infection. Only some cases in which the activity increased until 3 hr post-administration survived. These results suggest that rFeIFN-omega (KT-80) treatment enhanced the cellular immunity of normal dogs, and could exert significant therapeutic effects on only natural CPV infected dogs with induced continuous immunoenhancement. |
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Keywords: | CPV dog rFeIFN‐ω KT‐80 |
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