Synthesis of 25-hydroxy-[6,19,19'-2H3]vitamin D3 and 1 alpha,25-dihydroxy-[6,19,19'-2H3]vitamin D3. |
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| Authors: | R Ray D Vicchio A Yergey M F Holick |
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| Affiliation: | Vitamin D Laboratory, Boston University School of Medicine, MA 02118. |
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| Abstract: | Synthesis of polydeuterated analogs of 25-hydroxyvitamin D3 and 1 alpha,25-dihydroxy vitamin D3 are described. These analogs, containing stable isotope atoms at metabolically stable positions, are potentially useful in studies involving catabolism of hydroxylated metabolites of vitamin D3. |
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