The mechanism of C-4 demethylation during cholesterol biosynthesis. Evidence for a decarboxylation mechanism not involving a Schiff-base intermediate |
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| Authors: | D. C. Wilton and M. Akhtar |
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| Affiliation: | Department of Physiology and Biochemistry, University of Southampton, Southampton SO9 3TU, U.K. |
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| Abstract: | The conversion of 4,4-dimethylcholest-7-enol into 4alpha-methylcholest-7-enol by rat liver microsomal preparations involves the decarboxylation of a sterol 3-oxo-4alpha-carboxylic acid. By using an (18)O-labelled substrate it was shown that this decarboxylation does not involve a Schiff-base intermediate. |
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