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The stereochemistry of the Grignard reaction of steroidal 4,5-epoxy-3-ketones |
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| Authors: | Uyanik Cavit Malay Aslihan Ayna Azra S Hanson James R Hitchcock Peter B |
| Institution: | Department of Chemistry, Kocaeli University, Izmit 41300, Kocaeli, Turkey. cuyanik@kou.edu.tr |
| Abstract: | The stereochemistry of the addition of methylmagnesium bromide to a steroidal 4,5-epoxy-3-ketone has been shown to be determined by the stereochemistry of the epoxide. The epoxidation to the corresponding 3-alkyl-3-hydroxy-4-enes by per-acid was determined by the stereochemistry of the allylic alcohol. |
| Keywords: | Grignard reagents Per-acid Steroids Epoxides Enes Crystal structure |
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