Go contributes to olfactory reception in Drosophila melanogaster |
| |
Authors: | Abhishek Chatterjee Gregg Roman Paul E Hardin |
| |
Institution: | (1) Department of Biology and Center for Biological Clock Research, Texas A&M University, College Station, TX 77843, USA;(2) Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA |
| |
Abstract: | Background Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant
receptors have seven transmembrane domains like G-protein coupled receptors, they have an inverted membrane topology and function
as ligand-gated cation channels. Consequently, the involvement of cyclic nucleotides and G proteins in insect odor reception
is controversial. Since the heterotrimeric Goα subunit is expressed in Drosophila olfactory receptor neurons, we reasoned that Go acts together with insect odorant receptor cation channels to mediate odor-induced physiological responses. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|