Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells |
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| Authors: | Jingxian Zhang Robert J Lipinski Jerry J Gipp Aubie K Shaw Wade Bushman |
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| Affiliation: | (1) Department of Urology, University of Wisconsin-Madison, Madison, WI, USA |
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| Abstract: | Background Hedgehog (Hh) signaling from the urogenital sinus (UGS) epithelium to the surrounding mesenchyme plays a critical role in regulating ductal formation and growth during prostate development. The primary cilium, a feature of most interphase vertebrate cell types, serves as a required localization domain for Hh signaling transducing proteins. |
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