Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated α-hydroxycarboxylate ligands |
| |
Authors: | Rodrigo da Silva Maffei Jenicer K. U. Yokoyama-Yasunaka Danilo Ciccone Miguel Silvia Reni Bortolin Uliana Breno Pannia Espósito |
| |
Affiliation: | 1. Instituto de Química, Universidade de S?o Paulo, Av. Lineu Prestes 748, S?o Paulo, 05508-000, Brazil 2. Instituto de Ciências Biomédicas, Universidade de S?o Paulo, Av. Lineu Prestes 1374, S?o Paulo, 05508-000, Brazil
|
| |
Abstract: | In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL2 (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic medium, purified by crystallization and characterized by elemental analysis and electronic and infrared spectroscopies. In vitro experiments with Leishmania amazonensis promastigotes showed that the trifluorolactate derivative more active than its non-fluorinated counterpart. Our results indicate that fluorinated chelators may be interesting to increase metal toxicity and/or open new paths for metallodrug chemotherapy against leishmaniasis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|